Astrogorgia sp. from Saparua, Maluku: Phytochemical Content, Antimicrobial, Antioxidant, and Cytotoxicity Properties

Abstract

Abstract Gorgonian is one of marine invertebrates that is still underexplored as a source of bioactive compounds. This study aimed to discover the biological properties of Astrogorgia sp. and its phytochemical content. A consecutive extraction method using n-hexane, ethyl acetate and methanol was conducted to obtain secondary metabolites from the sample. Antimicrobial assay was performed against ESBL E. coli, MRSA, C. albicans, and M. furfur; cytotoxicity against P388 Murine Leukaemia Cancer Cells, antioxidant was tested using DPPH method. The consecutive extraction method gave yield (%) as follows: 0.21 ± 0.22 from n-hexane; 0.67 ± 0.17 from acetyl acetate; and 1.20 ± 0.50 from methanol. All fractions gave positive results on antibacterial assay against all pathogens while only gave antifungal activity against C. albicans. Methanol fraction had the highest antioxidant activity, while n-hexane fraction showed the best cytotoxicity.