Bacterial luminescent biosensors in the system for assessing the mechanisms of antibacterial activity of carbon-based nanomaterials

Abstract

Abstract The study presents the results of an analysis of possible mechanisms of antibacterial activity of nanocarbon compounds. It was found that the contact of carbon-based nanomaterials with bacterial cells is not accompanied by a violation of their structural integrity and the development of various types of stress (oxidative stress, reaction of the protein-chaperone system, SOS response). The result of this interaction is a change in the magnitude of the surface zeta potential of cells and the permeability of their membrane, which negatively affects the energy processes occurring in target cells. The direct manifestation of this condition is a decrease in the level of luminescence of luminescent strains and a loss of viability.