Supervision of The Complement System by Toxoplasma During Neural Infections (Areview)

Abstract

Abstract Chronic infections with Toxoplasma gondii occur in the brain of mammalian hosts. The understanding of the relationship between Toxoplasma gondii, CNS, and the immune system assists in comprehending how Toxoplasma affects the complement system and how it exerts a defense mechanism against Toxoplasma. This review focuses on the supervision of the complement system by Toxoplasma gondii during neural infections. There are three possible mechanisms by which the protozoan can invade the brain. Tachyzoites in bloodstreams multiply, invade, and bind to endothelial cells before migrating into parenchymas via transcellular crossing mechanisms. Secondly, the immune cells become like the Trojan horse, which carries intracellular parasites across the blood–brain barrier (BBB). In the third mechanical process, the BBB can directly be crossed through the brain at the tight junction (TJ) by the tachyzoites. It is concluded that C3 manipulation of the integrity of the BBB can be used to increase T.gondii invasion into the CNS..