Morphofunctional changes in rabbit thymus with simultaneous vaccination and disinsection

Abstract

Abstract The work carried out a morphometric study of the thymus of rabbits vaccinated with the associated vaccine against myxomatosis and viral hemorrhagic disease of rabbits (VHD) at a dose of 0.5 ml subcutaneously and treated with an insecticide preparation “Stronghold” (selamectin 6%) at a dose of 0.1 ml / kg at the withers … Chinchilla rabbits, live weight 2-2.5 kg, aged 6-8 months were used as experimental material. In total, 20 animals were examined. The thymus was examined by conventional histological methods. The nature of changes in the morphofunctional parameters of the thymus with the combined use of the investigated factors revealed a dependence on the time of application of the drug “Stronghold” in relation to the vaccine. Our studies on rabbit immunogenesis with simultaneous vaccination against myxomatosis and viral hemorrhagic disease of rabbits (VGBD) and treatment with the Stronghold insecticide with the active ingredient selamectin in the form of a 6% solution did not show significant morphofunctional changes in the thymus with increased stress load on a living organism.