Evaluation of the invitro antidiabetic and anti-cholesterols activity of selected plant extract

Abstract

Abstract Diabetic and hypercholesterolemia are the most common metabolic disorders in the world. The purpose of the study was to assess the anti-diabetic and anti-cholesterol effect of water leaf extract of Lagerstroemia speciosa, Cinnamomum parthenoxylon, and Oroxylum indicum in vitro. Those three plants are often used by the local community to treat diabetes and hypercholesterol. The water extract’s active ingredients are steroids and flavonoids. The flavonoid content was reported to be 51.89, 110.92, and 63.41 mg QE/g respectively. In vitro studies on hemoglobin glycosylation, showed that 30 ppm aqueous leaf extract of L. speciosa, C. parthenoxylon, and O. indicum showed considerable inhibition of hemoglobin glycosylation by 12.06 %, 33.25%, and 73.96%, compared to a positive control (metformin) was 30.6 %. The in vitro anti-cholesterol properties of O. indicum and C. parthenoxylon could lower cholesterol by 33% compared to simvastatin by 33.104%. According to the study’s findings, the water leaf extracts of O. indicum and C. parthenoxylon have excellent pharmaceutical potential and might be used as herbal remedy to manage diabetes and cholesterol. To verify this work, more in vitro and in vivo research is required.