The comparative analysis of the influence of fluorochinolones on the blood leucogram of chickens

Abstract

Abstract In the present research we study the changes in ratio of different kinds of leucocytes in chickens of Hisex Brown cross following the application of fluoroquinolone antibiotic drugs. In the study we used Ciprofloxacin, Ofloxacin, Levofloxacin, Moxifloxacin, Norfloxacin, Enrofloxacin. The control set was given pure drinking water throughout the experiment; each of the experimental groups was given water with one of the above-mentioned antibacterial fluoroquinolone drugs, the dosage being 200 mg/L. The leukogram contains the total number of leucocytes and the content of separate cell types and their total numbers. The study reveals significant and valid changes concerning the number of lymphocytes. On the seventh and the ninth days after the drug withdrawal all the fluoroquinolones except Ofloxacin caused lymphopenia. The valid changes in the number of pseudoeosinophils do not show clear tendencies, such changes are observed once under the influence of each drug on different days of the research. Levofloxacin, Enrofloxacin, Ofloxacin cause refractory basophilia. The application of antimicrobial fluoroquinolone drugs in the course of ten days results in changes in the ratio of different kinds of leucocytes in chicken blood, but at the conclusion of the experiment every value in the leukogram returns to physiological standard.