Effect of amino acid imbalance in the nutrition on the morphology of animal liver

Abstract

Abstract The article considers the influence of various forms of amino acid imbalance in diets on morphological changes in the liver of laboratory animals. An imbalance of amino acids caused a number of similar changes in the liver of animals. Liver sections revealed that hepatocytes had smoothed borders and areas with signs of granular dystrophy. The sinusoids and inter-protein spaces were overflowed with blood moulds. Small groups of lymphohistiocytic cells were presented in the parenchyma. Violation of the liver microcirculation contributed to the violation of metabolic processes in hepatocytes. Most of the hepatocytes were filled with yellow-orange fat droplets and had atrophied cytoplasm with nuclei shifted to the periphery. There were single cells with glycogen granules as well. The content of nucleic acids in tissues is an important indicator of the intensity of protein synthesis. Thus, in liver sections of groups 1, 2, 3 and 4, the cytoplasm of hepatocytes was less colored than in the control group, which indirectly indicates an increase in the intensity of protein synthesis in liver cells. Hemodynamic disorders in the form of dilated blood vessels and the appearance of stasis in groups 1, 2, 3 and 4 lead to difficulties in the penetration of amino acids to the sites of protein synthesis and, as a result, to a violation of metabolic processes in parenchymal liver cells.