The interconnection of the elemental composition and morphofunctional characteristics of placenta during the tobacco intoxication

Abstract

Abstract The aim of the research was to study the interconnection between the elemental composition and morphofunctional characteristics of the rat placenta during the tobacco intoxication. Determining the elemental composition of the placenta was performed using an Elan 9000 mass spectrometer and an Optima 2000 V atomic emission spectrometer. The morphofunctional characteristics of the placenta were studied by preparing the serial paraffin histological sections. Data processing was performed using the Mann-Whitney U-test. It was established that as the result of a passive smoking, the fertility of females decreased, the physical development of fetuses also decreased, the weight and thickness of the placenta declined, the number of fetal capillaries and maternal sinuses of the placenta decreased. The most common pathological changes in the histological structure of the placentas of the experimental groups were the development of foci of circulatory disorders, inflammatory and atrophic changes. When comparing the elemental composition of the experimental groups, lower values of magnesium and iron were found, against the background of higher values of lead and cadmium. Identified dislementasis in conjunction with the pathological changes in the placenta caused a placental insufficiency, which in turn led to the delay in fetal development of the fetus.