Synthesis of nanomagnetite coated with carboxymethyl kappa carrageenan (CMKC) as a binder of sodium diclofenac

Abstract

Abstract To increase the effectiveness of therapy and prevent such damage, nanocarriers can be used as drug carriers through intraarticular injection. The active ingredient of the drug is bound to the nanoparticle-wrapping membrane which is controlled by a magnetic field from the outside. The nanoparticles used in this study were nanomagnetites which were synthesized by the coprecipitation method. Then nanomagnetite is coated with a coating agent that can bind the active ingredients of the drug while preventing agglomeration and oxidation. The coating used carboxymethyl kappa-carrageenan (CMKC). CMKC synthesis was carried out by modifying kappa-carrageenan through two steps, alkalization of k-carrageenan using NaOH, to form alkoxy-k-carrageenan, then etherification of alkoxy-k-carrageenan with monochloroacetic acid (MCA) as reactant to produce carboxymethyl k-carrageenan (CMKC) in isopropanol and ethanol solvent media. The absorption of diclofenac sodium into nanomagnetite coatings was carried out on a phosphate buffer media of pH 7.4 with an absorption time of 30 minutes at room temperature. From the results of the research note that sodium diclofenac successfully adsorbed onto nanomagnetite coatings.