Beta-band modulation in the human hippocampus during a conflict response task
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Published:2020-11-11
Issue:6
Volume:17
Page:066003
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ISSN:1741-2560
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Container-title:Journal of Neural Engineering
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language:
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Short-container-title:J. Neural Eng.
Author:
Chen Kuang-Hsuan,
Gogia Angad SORCID,
Tang Austin MORCID,
Del Campo-Vera Roberto Martin,
Sebastian Rinu,
Nune George,
Wong JanelineORCID,
Liu Charles Y,
Kellis Spencer,
Lee Brian
Abstract
Abstract
Objective. Identify the role of beta-band (13–30 Hz) power modulation in the human hippocampus during conflict processing. Approach. We investigated changes in the spectral power of the beta band (13–30 Hz) as measured by depth electrode leads in the hippocampus during a modified Stroop task in six patients with medically refractory epilepsy. Previous work done with direct electrophysiological recordings in humans has shown hippocampal theta-band (3–8 Hz) modulation during conflict processing. Local field potentials sampled at 2 k Hz were used for analysis and a non-parametric cluster-permutation t-test was used to identify the time period and frequency ranges of significant power change during cue processing (i.e. post-stimulus, pre-response). Main results. In five of the six patients, we observe a statistically significant increase in hippocampal beta-band power during successful conflict processing in the incongruent trial condition (cluster-based correction for multiple comparisons, p < 0.05). There was no significant beta-band power change observed during the cue-processing period of the congruent condition in the hippocampus of these patients. Significance. The beta-power changes during conflict processing represented here are consistent with previous studies suggesting that the hippocampus plays a role in conflict processing, but it is the first time that the beta band has been shown to be involved in humans with direct electrophysiological evidence. We propose that beta-band modulation plays a role in successful conflict detection and automatic response inhibition in the human hippocampus as studied during a conflict response task.
Funder
Tianqiao and Chrissy Chen Brain-Machine Interface Center at Caltech
National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health
Taiwan-USC Postdoctoral Fellowship Program
Meira and Shaul G. Massry Foundation
Subject
Cellular and Molecular Neuroscience,Biomedical Engineering
Cited by
2 articles.
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