Abstract
Abstract
Background. The use of virtual reality (VR) as a rehabilitation tool has been shown to induce motor and cognitive improvements in different populations. Functional magnetic resonance imaging (fMRI) has been used to investigate neuroplasticity resulting from these treatments. We hypothesize that VR rehabilitation induces functional improvement and brain changes that can be detected by fMRI. Objective. To systematically review the effects of VR intervention on the cortical reorganization measured by fMRI and associated with functional improvement. Approach. We performed a systematic review of studies published between 2005 and 2021. Papers were retrieved from six databases using the following keywords: ‘motor rehabilitation’, ‘fMRI’ and ‘virtual reality’. Case studies, pre-post studies, cross-sectional studies, and randomized controlled trials published were included. Manuscripts were assessed by The National Institutes of Health study quality assessment tools to determine their quality. Main results. Twenty-three articles met our eligibility criteria: 18 about VR rehabilitation in stroke and five on other clinical conditions (older adults, cerebral palsy, and Parkinson’s disease). Changes in neural patterns of activation and reorganization were revealed in both the ipsilesional and the contralesional hemispheres. Results were located mainly in the primary motor cortex, sensorimotor cortex and supplementary motor area in post-stroke patients in the acute, subacute, and chronic rehabilitation phases, and were associated with functional improvement after VR intervention. Similar effects were observed in older adults and in patients with other neurological diseases with improved performance. Significance. Most stroke-related studies showed either restoration to normal or increase of activation patterns or relateralization at/to the ipsilesional hemisphere, with some also reporting a decrease in activity or extent of activation after VR therapy. In general, VR intervention demonstrated evidence of efficacy both in neurological rehabilitation and in performance improvement of older adults, accompanied by fMRI evidence of brain reorganization.
Funder
Sao Paulo Research Foundation
Coordination for the Improvement of Higher Education Personnel
Subject
Cellular and Molecular Neuroscience,Biomedical Engineering
Reference71 articles.
1. Recovery of standing balance and functional mobility after stroke;Garland;Arch. Phys. Med. Rehabil.,2003
2. People with stroke living in the community: attention deficits, balance, ADL ability and falls;Hyndman;Disabil. Rehabil.,2003
3. A review of standing balance recovery from stroke;Geurts;Gait Posture,2005
4. The world health report 2002—reducing risks, promoting healthy life;Guilbert;Educ. Health (Abingdon),2003
5. Prevalence of cerebral palsy, intellectual disability, hearing loss, and blindness, National Health Interview Survey, 2009–2016;McGuire;Disabil. Health J.,2019
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