Impact of electrode position on the dynamic range of a human auditory nerve fiber

Abstract

Abstract Objective. Electrodes of a cochlear implant generate spikes in auditory nerve fibers (ANFs). While the insertion depth of each of the electrodes is linked to a frequency section of the acoustic signal, the amplitude of the stimulating pulses controls the loudness of the related frequency band. However, in comparison to acoustic stimulation the dynamic range (DR) of an electrically stimulated ANF is quite small. Approach. The DR of an electrically stimulated ANF is defined as the interval of stimulus amplitudes that causes firing probabilities between 10% and 90%. A compartment model that includes sodium ion current fluctuations as the stochastic key component for spiking was evaluated for different electrode placements and fiber diameters. Main results. The DR is reversely related to ANF diameter. An increased DR is expected to improve the quality of auditory perception for CI users. Electrodes are often placed as close to the center axis of the cochlea as possible. The analysis of the simulated auditory nerve firing showed that this placement is disadvantageous for the DR of a selected ANF. Significance. Five times larger DRs are expected for electrodes close to the terminal of the dendrite or at mid-dendritic placement as opposed to electrodes close to the modiolus.