Chlorin e6-1,3-diphenylisobenzofuran polymer hybrid nanoparticles for singlet oxygen-detection photodynamic abaltion

Author:

Wang Xiao-HuiORCID,Wei Xiao-Fei,Liu Jin-Hua,Yang Wei,Liu Yuan-An,Cheng Kun,He Xiao-YingORCID,Fu Xiu-Li,Zhang Yu,Zhang Hong-Xin

Abstract

Abstract A dual-functional nanosysterm is developed by means of Chlorin e6 (Ce6) as photosensitizer and 1,3-Diphenylisobenzofuran (DPBF) as fluorescent singlet oxygen (1O2) probe. Under 660 nm laser irradiation, Ce6 exhibites efficient 1O2 generation, and subsequently the production of 1O2 is assessed by the ratiometric fluorescence of PFO and DPBF under one-photon and two-photon excitation mode. The nanoparticles with excellent biocompatibility can be internalized into Hela cells and applied for tumor treatment. For intracellular PDT, the nanoparticles perform a high phototoxicity, while the PDT proccess can be evaluated in time by monitoring fluorescence signals of DPBF. This theranostic nanosysterm provides a facile strategy to fabricate 1O2-detection PDT, which can realize accurate and efficient photodynamic therapy based on singlet oxygen detection.

Funder

National Nature Science Foundation of China

Aeronautical Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

IOP Publishing

Subject

Spectroscopy,General Materials Science,Instrumentation,Atomic and Molecular Physics, and Optics

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