Abstract
Abstract
Graphene oxide (GO) nanosheets were doped to zinc oxide (ZnO) nanoparticles using a facile chemical deposition method. X-ray diffraction (XRD) confirmed the presence of hexagonal structure and increased peaks broadening upon doping. Undoped and ZnO doped GO sheets showed morphology like nanoparticles, nanorods and flakes were observed under transmission and field emission electron microscopies respectively. An increase in absorption was observed in absorption spectra upon doping recorded via UV-visible spectroscopy. The hydrogen bonding between functional groups of GO and ZnO is responsible for limiting maximum drug loading efficiency. GO doped ZnO has higher drug loading efficiency of about 89% compared to ZnO (82%) and this trend reverse in drug releasing process. This study will provide an efficient design of the drug delivery system for dissolution enhancement according to the required drug release.
Funder
Higher Education Commission, Pakistan
Subject
Metals and Alloys,Polymers and Plastics,Surfaces, Coatings and Films,Biomaterials,Electronic, Optical and Magnetic Materials
Reference44 articles.
1. An overview of drug delivery vehicles for cancer treatment: nanocarriers and nanoparticles including photovoltaic nanoparticles;Chowdhury;J. Photochem. Photobiol., B,2016
2. Entrepreneurship, economic growth and public policy;Acs;Small Business Economics.,2007
3. The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics;Deng;Int. J. Nanomed.,2013
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