Modelling of acetaminophen release from hydroxyethylcellulose/polyacrylamide hydrogel

Author:

Díaz-Guerrero Abigail MORCID,Castillo-Miranda Claudia AORCID,Peraza-Vázquez HernánORCID,Morales-Cepeda Ana BORCID,Peña-Delgado Adrián FORCID,Rivera-Armenta José LORCID,Castro-Guerrero Carlos FORCID

Abstract

Abstract Hydroxyethylcellulose (HEC) is a biodegradable, biocompatible polymer which is responsive to the temperature and pH values that can be reached by the human body. Polyacrylamide (PAAm) is a biocompatible and absorbent material which is highly used as a Drug Delivery System (DDS) due to its swelling capacity. In this work, a composite of HEC and PAAm was synthesized at a ratio of 25/75 wt% in order to evaluate its use as a transdermal DDS for acetaminophen. Drug release tests were performed in a phosphate buffer solution (PBS) at 35, 37, and 39 °C. The Korsmeyer-Peppas model was presented as a mathematical optimization problem and solved by Differential Evolution (DE) algorithm. Additionally, drug release data was modelled by Multigene Symbolic Regression (MSR) based on Genetic Programming (GP) algorithm. A drug release mathematical model was generated by MSR. The model is capable to reliably describe the kinetics of acetaminophen release from HEC/PAAm and to predict the concentrations of drug that is released in times beyond the experiment runtime.

Funder

Instituto Politécnico Nacional

Tecnológico Nacional de México

Consejo Nacional de Ciencia y Tecnología

Publisher

IOP Publishing

Subject

Metals and Alloys,Polymers and Plastics,Surfaces, Coatings and Films,Biomaterials,Electronic, Optical and Magnetic Materials

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