Abstract
PurposeThis paper aims to evaluate the effect of consumption of a high-fat diet (HFD) rich with total saturated fats on adiposity and serum levels of vascular cell adhesion molecule (sVCAM-1), a biomarker of endothelial inflammation/dysfunction. Another aim is to evaluate whether supplementation of a phytosomal formulation of curcumin would reduce adiposity measures and sVCAM-1 levels in HFD rats.Design/methodology/approachThe study was conducted on 17 male rats which were allocated to one of three feeding regimen groups: normal diet (ND); HFD, or HFD with dietary phytosomal curcumin (HFD-C). Anthropometric measures were recorded weekly up to 20 weeks of feeding intervention, at the end of which, sVCAM-1 levels were also compared with one-way ANOVA and Tukey post-hoc analysis.FindingsThe HFD group had the greatest values for raw anthropometric data, and there was a group difference in anthropometric measures, however there was no significant difference between HFD and HFD-C for any measure. The gain at 20 weeks from initial values did reveal significant differences in weight and abdominal circumference between HFD and HFD-C groups. There were significant group differences in sVCAM-1 levels, with only HFD-C displaying significant lower levels than HFD group.Originality/valueThis is the first study that shows the capacity of a phytosomal formulation of curcumin in reducing adiposity and sVCAM-1 levels during daily intake of saturated fats above the recommended level. The results are promising in that this formulation can protect against endothelial inflammation/dysfunction, and can be used as complimentary therapy to suppress dyslipidemia/obesity-related cardiovascular complications.
Subject
Water Science and Technology,Agronomy and Crop Science,Ecology, Evolution, Behavior and Systematics,General Biochemistry, Genetics and Molecular Biology,General Business, Management and Accounting,General Computer Science,General Medicine,General Environmental Science,Education
Reference47 articles.
1. Adhesion molecules and chemokines; relation to anthropometric, body composition, biochemical and dietary variables;Nutricoin Hospitalaria,2014
2. Microencapsulated curcumin from Curcuma longa modulates diet-induced hypercholesterolemia in Sprague Dawley rats;Frontiers in Nutrition,2022
3. Obesity and risk of vascular disease: Importance of endothelium-dependent vasoconstriction;British Journal of Pharmacology,2012
4. Saturated fatty acid intake is associated with increased inflammation, conversion of kynurenine to tryptophan, and delta-9 desaturase activity in healthy humans;International Journal of Tryptophan Research,2020
5. Effects of phytosomal curcumin on anthropometric parameters, insulin resistance, cortisolemia and non-alcoholic fatty liver disease indices: A double-blind, placebo-controlled clinical trial;European Journal of Nutrition,2019