The study of the possibility of drug dissolution of gallbladder calculi

Author:

Dikman Ekaterina,Soldatov Alexey,Chirev Anatoly

Abstract

Purpose The purpose of this paper is to verify the possibility of ultrasonic intensification of drug dissolution of cholesterol calculi of the gallbladder using conventional ultrasound frequency and intensity from 0.1 to 0.5 W/cm2. Design/methodology/approach For research purposes, the physical model was developed containing pig bile, pig liver, pigskin, fat and muscles, as well as human cholesterol calculus removed by surgery and a drug with ursodeoxycholic acid. Findings The studies have shown the possibility of accelerating the drug dissolution of calculi of the gallbladder with ultrasound exposure. The ultrasound intensity of 0.4 W/cm2 is the most preferable to intensify the dissolution of calculus. Originality/value The results will be used to advance with development of the device and methodology for ultrasonic intensification of drug dissolution of gallbladder calculi.

Publisher

Emerald

Subject

Electrical and Electronic Engineering,Industrial and Manufacturing Engineering

Reference12 articles.

1. Ursodeoxycholic acid: a therapeutic niche in an internist’s practice;Terapevticheskii Arkhiv,2015

2. Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed;World Journal of Gastroenterology,2013

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