Pt electrode modified with β-cyclodextrin/polyaniline for electrochemical sensing of penicillin V

Abstract

Purpose A new electrochemical analysis based on ß-cyclodextrin (ß-CD) was developed for penicillin V (Peni-V) using polyaniline as a conducting polymer. Design/methodology/approach The preparation of modified electrode involves the incorporation of β-CD with membrane of polyaniline. Polyaniline, incorporating β-CD, was prepared by electrochemical polymerization method in a medium of hypochloride. Cyclic voltammetry and electrochemical impedance have been used to characterize this sensor. The detection and the kinetic study of modified platinum electrode are evaluated. Findings Results clearly indicate that β-CDs interfere with the polymerization mechanism with an inhibition factor. The inclusion phenomenon of β-CDs has been studied and applied to detect Peni-V. The principle of this electrochemical sensor is based on the chemical properties of β-CD, which were studied using the cyclic voltammetric method and impedance spectroscopy. The electrochemical behavior of Peni-V at concentrations between 10–8 and 10–2 M was measured versus Ag/AgCl at pH 7.4 and 30°C in a phosphate alkaline buffer. Relationship of Peni-V concentration in logarithmic mathematical form with current in potentiometric method and with resistance in impedimetric method were obtained. Originality/value The present study showed that the Pt electrode modified with Polyaniline–β-CD was an excellent candidate for sensitive penicillin analysis. The proposed electroanalytical technique is rapid, simple and inexpensive.