Author:
Koriem Khaled Mohamed Mohamed,Fadl Nevein Naim,El-Zayat Salwa Refat,Hosny Eman Nasr,Abbas El-Shamy Karima,Arbid Mahmoud Soliman,Morsy Fatma Adly,El-Azma Marwa Helmy
Abstract
Purpose
The purpose of this paper is to check the geranium oil and anise oil effect to inhibit inflammation in brain cerebral cortex and hippocampus areas in depression.
Design/methodology/approach
Depression defined as psychiatric disease and chronic mild stress (CMS) model a well-known animal model of depression that represented major symptoms occurred in human depression. Geranium oil and anise oil selected for such a study to check their anti-inflammatory effect in brain tissues in depressed animal model.
Findings
The brain cerebral cortex and hippocampus neurotransmitters serotonin, dopamine, norepinephrine, gamma aminobutyric acid (GABA) and interleukin (IL)-10 significantly decreased (p < 0.001) while brain cerebral cortex and hippocampus IL-1ß, IL-6, tumor necrosis factor-alpha (TNF-α) and Ki-67 levels significantly increased (p < 0.001) in CMS rats compared to control. The oral intake of venlafaxine drug, anise oil and geranium oil significantly increased (p < 0.001) serotonin, dopamine, norepinephrine, GABA and IL-10 while significantly decreased (p < 0.001) IL-1ß, IL-6, TNF-α and Ki-67 levels to approach normal levels in brain cerebral cortex and hippocampus areas compared with CMS rats.
Originality/value
Antidepressants used in depression treatment but these drugs are either too expensive or had side effects. Folklore and complementary medicine used in different diseases treatment due to cheap and available source. Geranium oil and anise oil had anti-inflammatory effect in brain cerebral cortex and hippocampus areas in CMS rats.
Subject
Nutrition and Dietetics,Food Science
Reference52 articles.
1. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the global burden of disease study;The Lancet,2017
2. Anxiolytic terpenoids and aromatherapy for anxiety and depression;Advances in Experimental Medicine and Biology,2020
3. Effects of essential oil of croton zehntneri, and of anethole and estragole on skeletal muscles;Journal of Ethnopharmacology,1995
4. Disruption of central nervous system barriers in multiple sclerosis;Biochimica et Biophysica Acta (Bba) – Molecular Basis of Disease,2011
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