Resveratrol supplementation and flow-mediated dilation: a systematic review

Abstract

PurposeThis study aims to systematically review randomized clinical trials (RCTs) evaluated the effects of resveratrol on vascular flow-mediated dilation (FMD).Design/methodology/approachAll published RCTs in English were systematically searched on PubMed and Scopus search engines up to October 2017. A total of 61 studies were found through search databases. The outcome variable of interest was FMD. Six articles which met inclusion criteria were included in this study.FindingsFrom six studies, four showed a significant improvement in FMD after resveratrol supplementation acutely or chronically in subjects with cardio-metabolic risk factors. Two other studies did not show any significant effect of resveratrol on FMD.Originality/valueThe authors systematically reviewed the effectiveness of resveratrol supplementation on FMD for the first time. The findings suggest that pure resveratrol supplementation may have beneficial effects on endothelium dependent vasodilatation indicator, FMD.