Use of Monte Carlo simulations with a realistic rat phantom for examining the correlation between hematopoietic system response and red marrow absorbed dose in Brown Norway rats undergoing radionuclide therapy with177Lu- and90Y-BR96 mAbs

Author:

Larsson Erik,Ljungberg Michael,Mårtensson Linda,Nilsson Rune,Tennvall Jan,Strand Sven-Erik,Jönsson Bo-Anders

Publisher

Wiley

Subject

General Medicine

Reference25 articles.

1. Determining maximal tolerable dose of the monoclonal antibody BR96 labeled with 90Y or 177Lu in rats: Establishment of a syngeneic tumor model to evaluate means to improve radioimmunotherapy;Mårtensson;Clin. Cancer Res.,2005

2. Correlation of red marrow radiation dosimetry with myelotoxicity: Empirical factors influencing the radiation-induced myelotoxicity of radiolabeled antibodies, fragments and peptides in pre-clinical and clinical settings;Behr;Cancer Biother. Radiopharm.,2002

3. Prediction of myelotoxicity based on bone marrow radiation-absorbed dose: Radioimmunotherapy studies using 90Y- and 177Lu-labeled J591 antibodies specific for prostate-specific membrane antigen;Vallabhajosula;J. Nucl. Med.,2005

4. Prediction of myelotoxicity using semi-quantitative marrow image scores;Lim;J. Nucl. Med.,1997

5. Prediction of myelotoxicity using radiation doses to marrow from body, blood and marrow sources;Lim;J. Nucl. Med.,1997

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