A general method for greatly improving the affinity of antibodies by using combinatorial libraries
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference32 articles.
1. Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda
2. Phage antibodies: filamentous phage displaying antibody variable domains
3. Mimicking Somatic Hypermutation: Affinity Maturation of Antibodies Displayed on Bacteriophage Using a Bacterial Mutator Strain
4. Thermodynamic Consequences of Grafting Enhanced Affinity toward the Mutated Antigen onto an Antibody
5. CDR Walking Mutagenesis for the Affinity Maturation of a Potent Human Anti-HIV-1 Antibody into the Picomolar Range
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