Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference34 articles.
1. [18] Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements
2. Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation
3. Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis
4. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
5. Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress
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