Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference22 articles.
1. MOLECULAR GENETIC ASPECTS OF HUMAN MITOCHONDRIAL DISORDERS
2. Mitochondrial Diseases in Man and Mouse
3. Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.
4. In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria.
5. Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes.
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