Author:
Seitzman Benjamin A.,Gratton Caterina,Laumann Timothy O.,Gordon Evan M.,Adeyemo Babatunde,Dworetsky Ally,Kraus Brian T.,Gilmore Adrian W.,Berg Jeffrey J.,Ortega Mario,Nguyen Annie,Greene Deanna J.,McDermott Kathleen B.,Nelson Steven M.,Lessov-Schlaggar Christina N.,Schlaggar Bradley L.,Dosenbach Nico U. F.,Petersen Steven E.
Abstract
Resting-state functional magnetic resonance imaging (fMRI) has provided converging descriptions of group-level functional brain organization. Recent work has revealed that functional networks identified in individuals contain local features that differ from the group-level description. We define these features as network variants. Building on these studies, we ask whether distributions of network variants reflect stable, trait-like differences in brain organization. Across several datasets of highly-sampled individuals we show that 1) variants are highly stable within individuals, 2) variants are found in characteristic locations and associate with characteristic functional networks across large groups, 3) task-evoked signals in variants demonstrate a link to functional variation, and 4) individuals cluster into subgroups on the basis of variant characteristics that are related to differences in behavior. These results suggest that distributions of network variants may reflect stable, trait-like, functionally relevant individual differences in functional brain organization.
Funder
HHS | NIH | National Institute of Neurological Disorders and Stroke
National Science Foundation
American Psychological Association
HHS | NIH | National Institute of Mental Health
Dart Neuroscience, LLC
James S. McDonnell Foundation
Publisher
Proceedings of the National Academy of Sciences
Cited by
149 articles.
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