Reduced default mode network functional connectivity in patients with recurrent major depressive disorder
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Published:2019-04-12
Issue:18
Volume:116
Page:9078-9083
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ISSN:0027-8424
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Container-title:Proceedings of the National Academy of Sciences
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language:en
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Short-container-title:Proc Natl Acad Sci USA
Author:
Yan Chao-Gan, Chen Xiao, Li Le, Castellanos Francisco Xavier, Bai Tong-Jian, Bo Qi-Jing, Cao Jun, Chen Guan-Mao, Chen Ning-Xuan, Chen Wei, Cheng Chang, Cheng Yu-Qi, Cui Xi-Long, Duan Jia, Fang Yi-Ru, Gong Qi-Yong, Guo Wen-Bin, Hou Zheng-Hua, Hu Lan, Kuang Li, Li Feng, Li Kai-Ming, Li Tao, Liu Yan-Song, Liu Zhe-Ning, Long Yi-Cheng, Luo Qing-Hua, Meng Hua-Qing, Peng Dai-Hui, Qiu Hai-Tang, Qiu Jiang, Shen Yue-Di, Shi Yu-Shu, Wang Chuan-YueORCID, Wang Fei, Wang Kai, Wang Li, Wang Xiang, Wang Ying, Wu Xiao-Ping, Wu Xin-Ran, Xie Chun-Ming, Xie Guang-Rong, Xie Hai-Yan, Xie Peng, Xu Xiu-Feng, Yang Hong, Yang Jian, Yao Jia-Shu, Yao Shu-Qiao, Yin Ying-Ying, Yuan Yong-Gui, Zhang Ai-Xia, Zhang Hong, Zhang Ke-Rang, Zhang Lei, Zhang Zhi-Jun, Zhou Ru-Bai, Zhou Yi-Ting, Zhu Jun-Juan, Zou Chao-Jie, Si Tian-Mei, Zuo Xi-NianORCID, Zhao Jing-Ping, Zang Yu-FengORCID
Abstract
Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology remains unclear. Most studies of functional brain networks in MDD have had limited statistical power and data analysis approaches have varied widely. The REST-meta-MDD Project of resting-state fMRI (R-fMRI) addresses these issues. Twenty-five research groups in China established the REST-meta-MDD Consortium by contributing R-fMRI data from 1,300 patients with MDD and 1,128 normal controls (NCs). Data were preprocessed locally with a standardized protocol before aggregated group analyses. We focused on functional connectivity (FC) within the default mode network (DMN), frequently reported to be increased in MDD. Instead, we found decreased DMN FC when we compared 848 patients with MDD to 794 NCs from 17 sites after data exclusion. We found FC reduction only in recurrent MDD, not in first-episode drug-naïve MDD. Decreased DMN FC was associated with medication usage but not with MDD duration. DMN FC was also positively related to symptom severity but only in recurrent MDD. Exploratory analyses also revealed alterations in FC of visual, sensory-motor, and dorsal attention networks in MDD. We confirmed the key role of DMN in MDD but found reduced rather than increased FC within the DMN. Future studies should test whether decreased DMN FC mediates response to treatment. All R-fMRI indices of data contributed by the REST-meta-MDD consortium are being shared publicly via the R-fMRI Maps Project.
Funder
National Key R&D Program of China National Natural Science Foundation of China Beijing Municipal Science & Technology Commission Department of Science and Technology, Zhejiang Province National Basic Research (973) Program
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Cited by
413 articles.
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