The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange
Author:
Publisher
Proceedings of the National Academy of Sciences
Subject
Multidisciplinary
Reference32 articles.
1. Homologous recombination in DNA repair and DNA damage tolerance
2. Mechanism of Eukaryotic Homologous Recombination
3. BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks
4. BRCA2: a universal recombinase regulator
5. RAD51 Interacts with the Evolutionarily Conserved BRC Motifs in the Human Breast Cancer Susceptibility Gene brca2
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1. Positive and negative regulators of RAD51/DMC1 in homologous recombination and DNA replication;DNA Repair;2024-02
2. DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation;Nature Communications;2023-01-26
3. New RAD51 Inhibitors to Target Homologous Recombination in Human Cells;Genes;2021-06-16
4. A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death;Cell Chemical Biology;2021-06
5. Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance;Nucleic Acids Research;2021-05-12
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