Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages-Reference-Cited by-同舟云学术

Benzo[a]pyrene diol epoxide adducts in DNA are potent suppressors of a normal topoisomerase I cleavage site and powerful inducers of other topoisomerase I cleavages

Published:2000-02-25 Issue:5 Volume:97 Page:2040-2045
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proceedings of the National Academy of Sciences

Author:

Pommier Y.,Kohlhagen G.,Pourquier P.,Sayer J. M.,Kroth H.,Jerina D. M.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference46 articles.

1. Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

2. DNA TOPOISOMERASES

3. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

4. Characterization of intra- and intermolecular DNA ligation mediated by eukaryotic topoisomerase I. Role of bipartite DNA interaction in the ligation process.

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