Nonspherical ultrasound microbubbles-Reference-Cited by-同舟云学术

Nonspherical ultrasound microbubbles

Published:2023-03-20 Issue:13 Volume:120 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Dasgupta Anshuman¹²³,Sun Tao²³⁴^ORCID,Palomba Roberto⁵^ORCID,Rama Elena¹,Zhang Yongzhi⁴^ORCID,Power Chanikarn⁴,Moeckel Diana¹,Liu Mengjiao¹,Sarode Apoorva²^ORCID,Weiler Marek¹^ORCID,Motta Alessandro¹,Porte Céline¹^ORCID,Magnuska Zuzanna¹,Said Elshafei Asmaa¹,Barmin Roman¹,Graham Adam²,McClelland Arthur²^ORCID,Rommel Dirk⁶⁷^ORCID,Stickeler Elmar⁸,Kiessling Fabian¹,Pallares Roger M.¹,De Laporte Laura⁶⁷⁹,Decuzzi Paolo⁵^ORCID,McDannold Nathan⁴,Mitragotri Samir²³,Lammers Twan¹

Affiliation:

1. Institute for Experimental Molecular Imaging, Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany

2. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138

3. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115

4. Focused Ultrasound Laboratory, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115

5. Laboratory of Nanotechnology for Precision Medicine, Istituto Italiano di Tecnologia, 16163 Genova, Italy

6. DWI−Leibniz Institute for Interactive Materials, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany

7. Institute of Technical and Macromolecular Chemistry, Polymeric Biomaterials, Rheinisch-Westfälische Technische Hochschule University Aachen, 52074 Aachen, Germany

8. Department of Obstetrics and Gynecology, Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany

9. Advanced Materials for Biomedicine, Institute of Applied Medical Engineering, Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany

Abstract

Surface tension provides microbubbles (MB) with a perfect spherical shape. Here, we demonstrate that MB can be engineered to be nonspherical, endowing them with unique features for biomedical applications. Anisotropic MB were generated via one-dimensionally stretching spherical poly(butyl cyanoacrylate) MB above their glass transition temperature. Compared to their spherical counterparts, nonspherical polymeric MB displayed superior performance in multiple ways, including i) increased margination behavior in blood vessel–like flow chambers, ii) reduced macrophage uptake in vitro, iii) prolonged circulation time in vivo, and iv) enhanced blood–brain barrier (BBB) permeation in vivo upon combination with transcranial focused ultrasound (FUS). Our studies identify shape as a design parameter in the MB landscape, and they provide a rational and robust framework for further exploring the application of anisotropic MB for ultrasound-enhanced drug delivery and imaging applications.

Funder

European Commission

EC | European Research Council

German Research Foundation

John A. Paulson School of Engineering and Applied Sciences at Harvard University

National Science Foundation

HHS | NIH | Office of Extramural Research, National Institutes of Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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