Kidney-resident innate-like memory γδ T cells control chronic <i>Staphylococcus aureus</i> infection of mice-Reference-Cited by-同舟云学术

Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice

Published:2022-12-27 Issue:1 Volume:120 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Bertram Tabea¹^ORCID,Reimers Daniel¹^ORCID,Lory Niels C.¹,Schmidt Constantin¹^ORCID,Schmid Joanna¹^ORCID,C. Heinig Lisa¹^ORCID,Bradtke Peter¹,Rattay Guido²^ORCID,Zielinski Stephanie³,Hellmig Malte⁴^ORCID,Bartsch Patricia⁴⁵^ORCID,Rohde Holger⁵^ORCID,Nuñez Sarah⁶⁷^ORCID,Rosemblatt Mariana V.⁶^ORCID,Bono Maria Rosa⁸^ORCID,Gagliani Nicola²⁹,Sandrock Inga¹⁰,Panzer Ulf⁴¹¹,Krebs Christian F.⁴¹¹^ORCID,Meyer-Schwesinger Catherine³^ORCID,Prinz Immo¹⁰¹¹¹²^ORCID,Mittrücker Hans-Willi¹¹¹^ORCID

Affiliation:

1. Institute for Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

2. I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

3. Institute of Cellular and Integrative Physiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

4. III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

5. Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

6. Facultad de Medicina y Ciencia, Universidad San Sebastián 7510602, Sede Los Leones, Chile

7. Centro Ciencia & Vida 7780272, Santiago, Chile

8. Department of Biology, Faculty of Sciences, Universidad de Chile, Las Palmeras 3425, Nunoa 7800003, Chile

9. Immunology and Allergy Unit, Department of Medicine, Karolinska Institute and University Hospital, Solna, Stockholm 17176, Sweden

10. Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany

11. Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

12. Institute of Systems Immunology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany

Abstract

γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A + during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection.

Funder

Deutsche Forschungsgemeinschaft

ANID/BASAL

Conicyt/FONDEQUIP

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2210490120

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