Affiliation:
1. Molecular, Cellular, and Development/UMR5077, Centre de Biologie Intégrative, Toulouse Cedex 9 31062, France
Abstract
Hematopoietic stem and progenitor cells maintain blood cell homeostasis by integrating various cues provided by specialized microenvironments or niches. Biomechanical forces are emerging as key regulators of hematopoiesis. Here, we report that mechanical stimuli provided by blood flow in the vascular niche control
Drosophila
hematopoiesis. In vascular niche cells, the mechanosensitive channel Piezo transduces mechanical forces through intracellular calcium upregulation, leading to Notch activation and repression of FGF ligand transcription, known to regulate hematopoietic progenitor maintenance. Our results provide insight into how the vascular niche integrates mechanical stimuli to regulate hematopoiesis.
Funder
Fondation pour la Recherche Médicale
Ligue Contre le Cancer
China Scholarship Council
Centre National de la Recherche Scientifique
Publisher
Proceedings of the National Academy of Sciences
Cited by
1 articles.
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1. Pumping up the blood progenitors by Piezo;Proceedings of the National Academy of Sciences;2023-05-25