Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood

Author:

Turner Gary R.1,Hewan Patrick1,Wearn Alfie2,van Dooren Roel3,Wyatt Lindsay1,Leppert Ilana R.4,Baracchini Giulia2ORCID,Hughes Colleen2,Williams Kayla M.2,Sylvain Elisabeth5,Tremblay-Mercier Jennifer5,Poirier Judes56,Villeneuve Sylvia456ORCID,Tardif Christine247,Spreng R. Nathan24568ORCID, ,Aumont-Rodrigue Gabriel,Badawy Mohamed,Baillet Sylvain,Bailly Julie,Baril Andree-Ann,Bohbot Veronique,Boisvert Lianne,Breitner John C.S.,Chakravarty Mallar,Collins Louis,Cunningham Nolan-Patrick,Dadar Mahsa,Das Samir,Dauar-Tedeschi Marina,Dery Christine,Ducharme Simon,Élie Marie Josée,Evans Alan,Fajardo Valdez Alfonso,Fonov Vladimir,Gallago Jonathan,Geddes Maiya R.,Hoge Rick,Hudon Louise,Ituria-Medina Yasser,Javanray Mohammadali,Jean Gabriel,Labonte Anne,Lalancette Marc,Munter Lisa-Marie,Bruneau Laurence Maligne,Menes Julien,Mohammediyan Bery,Multhaup Gerhard,Capota Eugenia Nita,Ourry Valentin,Picard Cynthia,Poirier Judes,Qiu Ting,Quesnel Marc James,Rajah Natasha,Raoult Jean-Michel,Remz Jordana,Rosa-Neto Pedro,Soucy Jean-Paul,Spreng R. Nathan,St-Onge Frederic,Sylvain Elisabeth,Tardif Christine,Tremblay-Mercier Jennifer,Tullo Stephanie,Vachon-Presseau Etienne,Villeneuve Sylvia,Yakoub Yara

Affiliation:

1. Department of Psychology, York University, Toronto, ON M3J 1P3, Canada

2. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada

3. Institutes of Psychology & Brain and Cognition, Leiden University, Leiden 2300 RC, The Netherlands

4. McConnell Brain Imaging Centre, McGill University, Montreal, QC H2A 2B4, Canada

5. Douglas Mental Health University Institute, Verdun, QC H4H 1R3, Canada

6. Department of Psychiatry, McGill University, Montreal, QC H3A 1A1, Canada

7. Department of Biomedical Engineering, McGill University, Montreal, QC H3A 2B4, Canada

8. Department of Psychology, McGill University, Montreal, QC H3A 1G1, Canada

Abstract

Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges in older adulthood would be associated with lower microstructural integrity of the locus coeruleus. Leveraging in vivo histological methods from quantitative MRI-magnetic transfer saturation—we provide evidence that older age is associated with lower locus coeruleus integrity. Critically, we demonstrate that an exploitation bias in older adulthood, assessed with a foraging task, is sensitive and specific to lower locus coeruleus integrity. Because the locus coeruleus is uniquely vulnerable to Alzheimer’s disease pathology, our findings suggest that aging, and a presymptomatic trajectory of Alzheimer’s related decline, may fundamentally alter decision-making abilities in later life.

Funder

Alzheimer's Association

HHS | NIH | National Institute on Aging

Canadian Government | Canadian Institutes of Health Research

Publisher

Proceedings of the National Academy of Sciences

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3