Author:
Muntyan Maria S.,Cherepanov Dmitry A.,Malinen Anssi M.,Bloch Dmitry A.,Sorokin Dimitry Y.,Severina Inna I.,Ivashina Tatiana V.,Lahti Reijo,Muyzer Gerard,Skulachev Vladimir P.
Abstract
Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb3 cytochromes), which are widespread among pathogenic bacteria, are the least understood. In particular, the proton-pumping machinery of these Coxs has not yet been elucidated despite the availability of X-ray structure information. Here, we report the discovery of the first (to our knowledge) sodium-pumping Cox (Scox), a cbb3 cytochrome from the extremely alkaliphilic bacterium Thioalkalivibrio versutus. This finding offers clues to the previously unknown structure of the ion-pumping channel in the C-type Coxs and provides insight into the functional properties of this enzyme.
Funder
Russian Foundation for Basic Research
Russian Scientific Foundation
Publisher
Proceedings of the National Academy of Sciences
Cited by
28 articles.
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