Patterning of frontal cortex subdivisions by Fgf17

Abstract

The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss ofFgf17selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus,Fgf17functions similar toFgf8in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.