A small-molecule therapeutic lead for Huntington's disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse-Reference-Cited by-同舟云学术

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A small-molecule therapeutic lead for Huntington's disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse

Published:2007-10-09 Issue:42 Volume:104 Page:16685-16689
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proceedings of the National Academy of Sciences

Author:

Chopra V.,Fox J. H.,Lieberman G.,Dorsey K.,Matson W.,Waldmeier P.,Housman D. E.,Kazantsev A.,Young A. B.,Hersch S.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference28 articles.

1. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

2. Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease

3. Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

4. Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

5. Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

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1. Developmental and physiological impacts of pathogenic human huntingtin protein in the nervous system;2024-09-02

2. Neurodegenerative disease: New hopes and perspectives;Current Molecular Medicine;2023-09-07

3. The Emerging Landscape of Small-Molecule Therapeutics for the Treatment of Huntington’s Disease;Journal of Medicinal Chemistry;2022-12-09

4. Molecular Strategies to Target Protein Aggregation in Huntington’s Disease;Frontiers in Molecular Biosciences;2021-11-12

5. Protein Aggregation Inhibitors as Disease-Modifying Therapies for Polyglutamine Diseases;Frontiers in Neuroscience;2021-02-12

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