The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms?-Reference-Cited by-同舟云学术

The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms?

Published:2001-11-20 Issue:24 Volume:98 Page:14033-14037
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proceedings of the National Academy of Sciences

Author:

Akwa Y.,Ladurelle N.,Covey D. F.,Baulieu E.-E.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Reference33 articles.

1. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

2. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive.

3. Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat

4. Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

5. Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition

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