Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia

Author:

Horn Andreas123ORCID,Reich Martin M.4,Ewert Siobhan1,Li Ningfei1ORCID,Al-Fatly Bassam1,Lange Florian4,Roothans Jonas4,Oxenford Simon1,Horn Isabel1,Paschen Steffen5ORCID,Runge Joachim6,Wodarg Fritz7,Witt Karsten8,Nickl Robert C.9ORCID,Wittstock Matthias10,Schneider Gerd-Helge11,Mahlknecht Philipp12,Poewe Werner12,Eisner Wilhelm13,Helmers Ann-Kristin14,Matthies Cordula9,Krauss Joachim K.6,Deuschl Günther5ORCID,Volkmann Jens4,Kühn Andrea A.1ORCID

Affiliation:

1. Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany

2. Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115

3. Massachusetts General Hospital Neurosurgery, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114

4. Department of Neurology, Julius-Maximilians University Würzburg, 97070 Würzburg, Germany

5. Department of Neurology, University Kiel, 24118 Kiel, Germany

6. Department of Neurosurgery, Medical School Hannover, 30625 Hannover, Germany

7. Department of Radiology, University Kiel, 24118 Kiel, Germany

8. Department of Neurology, University Oldenburg, 26129 Oldenburg, Germany

9. Department of Neurosurgery, Julius-Maximilians University Würzburg, 97070 Würzburg, Germany

10. Department of Neurology, University Rostock, 18051 Rostock, Germany

11. Department of Neurosurgery, Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany

12. Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria

13. Department of Neurosurgery, Innsbruck Medical University, 6020 Innsbruck, Austria

14. Department of Neurosurgery, University Kiel, 24118 Kiel, Germany

Abstract

Significance We studied deep brain stimulation effects in two types of dystonia and conclude that different specific connections between the pallidum and thalamus are responsible for optimal treatment effects. Since alternative treatment options for dystonia beyond deep brain stimulation are scarce, our results will be crucial to maximize treatment outcome in this population of patients.

Funder

Dystonia Medical Research Foundation

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Luft- und Raumfahrt

Foundation for OCD Research

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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