HYL1-CLEAVAGE SUBTILASE 1 (HCS1) suppresses miRNA biogenesis in response to light-to-dark transition-Reference-Cited by-同舟云学术

HYL1-CLEAVAGE SUBTILASE 1 (HCS1) suppresses miRNA biogenesis in response to light-to-dark transition

Published:2022-02-04 Issue:6 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Jung Hyun Ju¹^ORCID,Choi Suk Won¹^ORCID,Boo Kyung-Hwan²^ORCID,Kim Jee-Eun¹,Oh Young Kyoung¹^ORCID,Han Min Kyun¹^ORCID,Ryu Moon Young³,Lee Chang Woo³,Møller Christian¹^ORCID,Shah Pratik¹^ORCID,Kim Gu Min¹,Yang Woorim¹,Cho Seok Keun³,Yang Seong Wook¹

Affiliation:

1. Department of Systems Biology, Institute of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea

2. Subtropical/Tropical Organism Gene Bank, Department of Biotechnology, College of Applied Life Science, Jeju National University, Jeju 63243, Korea

3. Xenohelix Research Institute, Incheon 21984, Korea

Abstract

Significance HYPONASTIC LEAVES 1 (HYL1)-CLEAVAGE SUBTILASE 1 (HCS1) is a novel negative regulator of microRNA (miRNA) biogenesis that degrades HYL1 in the cytoplasm. Furthermore, cytoplasm CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) E3 ligase inhibit HCS1-mediated HYL1 degradation. The COP1-HYL1-HCS1 network may integrate two essential cellular pathways: the miRNA-biogenetic pathway and light signaling pathway. Our finding suggests a regulatory pathway in the miRNA-biogenetic system.

Funder

National Research Foundation of Korea

Samsung Science and Technology Foundation

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2116757119

Reference70 articles.

1. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

2. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans