Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction-Reference-Cited by-同舟云学术

Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction

Published:2022-02-16 Issue:8 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Reizine Florian¹²³^ORCID,Grégoire Murielle¹²^ORCID,Lesouhaitier Mathieu¹²³^ORCID,Coirier Valentin¹²³^ORCID,Gauthier Juliette¹²,Delaloy Céline¹²^ORCID,Dessauge Elise²^ORCID,Creusat Florent²,Uhel Fabrice¹²³,Gacouin Arnaud³⁴,Dessauge Frédéric⁵^ORCID,Le Naoures Cécile⁶,Moreau Caroline⁷^ORCID,Bendavid Claude⁷^ORCID,Daniel Yoann⁸,Petitjean Kilian⁸^ORCID,Bordeau Valérie⁹^ORCID,Lamaison Claire²,Piau Caroline¹⁰,Cattoir Vincent⁹¹⁰¹¹,Roussel Mikael¹²^ORCID,Fromenty Bernard⁸^ORCID,Michelet Christian³⁴,Le Tulzo Yves³⁴,Zmijewski Jaroslaw¹²,Thibault Ronan¹³¹⁴,Cogné Michel¹²^ORCID,Tarte Karin¹²,Tadié Jean-Marc²³⁴^ORCID

Affiliation:

1. Laboratoire Suivi Immunologique des Thérapeutiques Innovantes, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France

2. INSERM, Microenvironment, Cell Differentiation, Immunology, and Cancer–UMR_S1236, Établissement française du sang Bretagne, Université de Rennes 2, F-35000 Rennes, France

3. Service des Maladies Infectieuses et Réanimation Médicale, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France

4. INSERM, Centre d’Investigation Clinique de Rennes, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France

5. PEGASE, INRAE, Institut Agro, 35590 Saint Gilles, France

6. Laboratoire d’anatomie pathologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France

7. Laboratoire de Biochimie, Pôle Biologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France

8. UMR_A 1341, UMR_S 1241, INSERM, Institut de Nutrition, Métabolismes et Cancer, Institut National de Recherche Agronomique, Université de Rennes 2, F-35000 Rennes, France

9. BACTERIAL REGULATORY RNAS AND MEDICINE–UMR_S 1230, INSERM, Université de Rennes 2, F-35000 Rennes, France

10. Service de Bactériologie, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France

11. Centre National de Référence de la Résistance aux Antibiotique (laboratoire associé “Entérocoques”), Centre Hospitalier Universitaire de Rennes, F-35043 Rennes, France

12. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294

13. INSERM, Service d’Endocrinologie, Diabétologie et Nutrition, Institut National de Recherche Agronomoque, Centre Hospitalier Universitaire de Rennes, F-35033 Rennes, France

14. INSERM, Institut de Nutrition, Métabolismes et Cancer, Institut National de Recherche Agronomique, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France

Abstract

Significance Since sepsis induces a sustained immunosuppression responsible for secondary infections acquisition and late mortality, restoring immune function would result in a better outcome. Given the role of arginine deficiency in T cell dysfunction, the evaluation of restoring arginine availability in sepsis has to be explored. Using an animal model of sepsis, we demonstrated that increasing arginine availability enhanced mitochondrial T cell function and decreased sepsis-induced immunosuppression.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2115139119

Reference54 articles.

1. Severe Sepsis and Septic Shock

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