The mouse brain after foot shock in four dimensions: Temporal dynamics at a single-cell resolution

Author:

Bonapersona Valeria1ORCID,Schuler Heike12ORCID,Damsteegt Ruth1,Adolfs Youri1,Pasterkamp R. Jeroen1ORCID,van den Heuvel Martijn P.3,Joëls Marian14,Sarabdjitsingh R. Angela1

Affiliation:

1. Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht 3584 CG, The Netherlands

2. Integrated Program in Neuroscience, McGill University, Montréal, QC H3A 1A1, Canada

3. Connectome Lab, Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands

4. University Medical Center Groningen, Groningen 9713 GZ, The Netherlands

Abstract

Significance Acute stress involves the majority of brain areas, which can be sequentially organized in functional brain networks as shown by our study with foot shock in mice. We used whole-brain microscopy to investigate different spatial resolutions over time. From mesoscale region–based analyses, we identified the order of activation of brain areas. With single-cell analyses, we analyzed shifts in activation over time within small nuclei—a result impossible to achieve with functional MRI’s resolution. These findings required the development of a four-dimensional (4D) analytical pipeline, which is made available as an R package. This “atlas” of foot shock can be visualized in 4D in our interactive web portal.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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