Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation

Author:

Pascual-Torner Maria12ORCID,Carrero Dido1ORCID,Pérez-Silva José G.1ORCID,Álvarez-Puente Diana1,Roiz-Valle David1ORCID,Bretones Gabriel1ORCID,Rodríguez David1ORCID,Maeso Daniel1ORCID,Mateo-González Elena2,Español Yaiza1ORCID,Mariño Guillermo34ORCID,Acuña José Luis2ORCID,Quesada Víctor1ORCID,López-Otín Carlos1

Affiliation:

1. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Ciberonc, Universidad de Oviedo, Oviedo, 33006, Spain

2. Observatorio Marino de Asturias, Departamento de Biología de Organismos y Sistemas, Universidad de Oviedo, Oviedo, 33006, Spain

3. Departamento de Biología Funcional, Facultad de Medicina, Universidad de Oviedo, Oviedo, 33006, Spain

4. Autophagy and Metabolism Lab, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, 33011, Spain

Abstract

Turritopsis dohrnii is the only metazoan able to rejuvenate repeatedly after its medusae reproduce, hinting at biological immortality and challenging our understanding of aging. We present and compare whole-genome assemblies of T. dohrnii and the nonimmortal Turritopsis rubra using automatic and manual annotations, together with the transcriptome of life cycle reversal (LCR) process of T. dohrnii. We have identified variants and expansions of genes associated with replication, DNA repair, telomere maintenance, redox environment, stem cell population, and intercellular communication. Moreover, we have found silencing of polycomb repressive complex 2 targets and activation of pluripotency targets during LCR, which points to these transcription factors as pluripotency inducers in T. dohrnii . Accordingly, we propose these factors as key elements in the ability of T. dohrnii to undergo rejuvenation.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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