Two kinds of memory signals in neurons of the human hippocampus

Abstract

Significance Episodic memories represent the “what,” “when,” and “where” of specific episodes. In epilepsy patients, we detected single-unit activity reflecting episodic memory only in the hippocampus. This neural signal is sparsely coded and pattern-separated, consistent with predictions from neurocomputational models. We also detected single-unit activity reflecting a generic memory signal, coding whether an item is old or new without item-specific episodic information. Similar to concept cells, this generic repetition/novelty neural signal was found in multiple brain regions, including the hippocampus. In contrast, the item-specific signal was found only in the hippocampus. Our results indicate the coexistence of two memory signals in the human brain and suggest that the sparsely coded, hippocampus-specific signal is fundamental, whereas the often-studied generic signal is derivative.