Neutrophil and natural killer cell imbalances prevent muscle stem cell–mediated regeneration following murine volumetric muscle loss-Reference-Cited by-同舟云学术

Neutrophil and natural killer cell imbalances prevent muscle stem cell–mediated regeneration following murine volumetric muscle loss

Published:2022-04-04 Issue:15 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Larouche Jacqueline A.¹²^ORCID,Fraczek Paula M.¹²^ORCID,Kurpiers Sarah J.¹,Yang Benjamin A.¹²^ORCID,Davis Carol³^ORCID,Castor-Macias Jesus A.¹²^ORCID,Sabin Kaitlyn¹²,Anderson Shannon⁴,Harrer Julia⁴^ORCID,Hall Matthew¹,Brooks Susan V.¹³^ORCID,Jang Young C.⁴⁵^ORCID,Willett Nick⁶,Shea Lonnie D.¹,Aguilar Carlos A.¹²⁷^ORCID

Affiliation:

1. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109

2. Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109

3. Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109

4. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332

5. School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332

6. Phil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR 97403

7. Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109

Abstract

SignificanceSkeletal muscle is one of the largest tissues in the body and can regenerate when damaged through a population of resident muscle stem cells. A type of muscle trauma called volumetric muscle loss overwhelms the regenerative capacity of muscle stem cells and engenders fibrotic supplantation. A comparison of muscle injuries resulting in regeneration or fibrosis revealed that intercellular communication between neutrophils and natural killer cells impacts muscle stem cell-mediated repair. Perturbation of neutrophil–natural killer cell interactions resulted in a variation of healing outcomes and suggested that immunomodulatory interventions can be effective to prevent aberrant healing outcomes.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2111445119

Reference95 articles.

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5. Characterization of Extremity Wounds in Operation Iraqi Freedom and Operation Enduring Freedom

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