Stone Age <i>Yersinia pestis</i> genomes shed light on the early evolution, diversity, and ecology of plague-Reference-Cited by-同舟云学术

Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague

Published:2022-04-12 Issue:17 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Andrades Valtueña Aida¹²^ORCID,Neumann Gunnar U.¹²,Spyrou Maria A.¹³,Musralina Lyazzat²⁴⁵^ORCID,Aron Franziska²⁶^ORCID,Beisenov Arman⁷^ORCID,Belinskiy Andrey B.⁸,Bos Kirsten I.¹,Buzhilova Alexandra⁹^ORCID,Conrad Matthias¹⁰,Djansugurova Leyla B.⁵^ORCID,Dobeš Miroslav¹¹^ORCID,Ernée Michal¹¹^ORCID,Fernández-Eraso Javier¹²^ORCID,Frohlich Bruno¹³,Furmanek Mirosław¹⁴^ORCID,Hałuszko Agata¹⁴¹⁵,Hansen Svend¹⁶^ORCID,Harney Éadaoin¹⁷¹⁸,Hiss Alina N.¹²,Hübner Alexander¹¹⁹^ORCID,Key Felix M.¹²⁰^ORCID,Khussainova Elmira⁵,Kitov Egor²¹²²²³^ORCID,Kitova Alexandra O.²⁴,Knipper Corina²⁵^ORCID,Kühnert Denise²⁶,Lalueza-Fox Carles²⁷,Littleton Judith²⁸,Massy Ken²⁹^ORCID,Mittnik Alissa¹⁸³⁰,Mujika-Alustiza José Antonio¹²^ORCID,Olalde Iñigo¹⁸²⁷³¹,Papac Luka²^ORCID,Penske Sandra¹²,Peška Jaroslav³²,Pinhasi Ron³³^ORCID,Reich David¹⁸³⁰^ORCID,Reinhold Sabine¹⁶^ORCID,Stahl Raphaela²^ORCID,Stäuble Harald¹⁰,Tukhbatova Rezeda I.²³⁴³⁵^ORCID,Vasilyev Sergey²¹^ORCID,Veselovskaya Elizaveta²¹,Warinner Christina¹¹⁹³⁶^ORCID,Stockhammer Philipp W.¹²⁹,Haak Wolfgang¹^ORCID,Krause Johannes¹^ORCID,Herbig Alexander¹^ORCID

Affiliation:

1. Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany

2. Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany

3. Institute for Archaeological Sciences, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany

4. Biology and Biotechnology Faculty, Al-Farabi Kazakh National University, 050040 Almaty, Kazakhstan

5. Institute of Genetics and Physiology, Al-Farabi Kazakh National University, Almaty, 050060 Kazakhstan

6. Faculty of Mathematics and Computer Science, Friedrich-Schiller University, 07743 Jena, Germany

7. Begazy-Tasmola Research Center of History and Archeology, 050008 Almaty, Kazakhstan

8. Nasledie Cultural Heritage Unit, 355006 Stavropol, Russian Federation

9. Research Institute and Museum of Anthropology, Lomonosov Moscow State University, 125009 Moscow, Russian Federation

10. Department of Heritage Management, Archaeological Heritage Office Saxony, 01108 Dresden, Germany

11. Department of Prehistoric Archaeology, Institute of Archaeology, Czech Academy of Sciences, 11801 Prague, Czech Republic

12. Department of Geography, Prehistory, and Archaeology, University of the Basque Country, Vitoria-Gasteiz, 01006 Spain

13. Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560

14. Institute of Archaeology, University of Wrocław, 50139 Wrocław, Poland

15. Archeolodzy.org Foundation, 50316 Wrocław, Poland

16. Eurasia-Department, German Archaeological Institute, 14195 Berlin, Germany

17. Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138

18. Department of Genetics, Harvard Medical School, Boston, MA 02115

19. Faculty of Biological Sciences, Friedrich-Schiller University, 07743 Jena, Germany

20. Evolutionary Pathogenomics, Max Planck Institute for Infection Biology, 10117 Berlin, Germany

21. Institute of Ethnology and Anthropology, Russian Academy of Science, 119991 Moscow, Russian Federation

22. Research Laboratory of Paleoanthropological Study, Institute of Archaeology named after A.Kh Margulan, Almaty, 50010 Kazakhstan

23. History Department, Al-Farabi Kazakh National University, 050040 Almaty, Kazakhstan

24. Centre for Egyptological Studies of the Russian Academy of Sciences, Russian Academy of Sciences, 119991 Moscow, Russian Federation

25. Curt Engelhorn Center Archaeometry, 68159 Mannheim, Germany

26. Transmission, Infection, Diversification & Evolution Group, Max Planck Institute for the Science of Human History, 07745 Jena, Germany

27. Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas-Universitat Pompeu Fabra, 08003 Barcelona, Spain

28. Department of Anthropology, University of Auckland, 01010 Auckland, New Zealand

29. Institute for Pre- and Protohistoric Archaeology and Archaeology of the Roman Provinces, Ludwig Maximilian University Munich, 80539 Munich, Germany

30. Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138

31. BIOMICs Research Group, University of the Basque Country Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, 01006 Vitoria-Gasteiz, Spain

32. Archaeological Centre, 779 00 Olomouc, Czech Republic

33. Department of Evolutionary Anthropology, University of Vienna, 1030 Vienna, Austria

34. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, 420008 Russian Federation

35. Laboratory for Structural Analysis of Biomacromolecules, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, 420111 Kazan, Russian Federation

36. Department of Anthropology, Harvard University, Cambridge, MA 02138

Abstract

Significance The bacterium Yersinia pestis has caused numerous historically documented outbreaks of plague and research using ancient DNA could demonstrate that it already affected human populations during the Neolithic. However, the pathogen’s genetic diversity, geographic spread, and transmission dynamics during this early period of Y. pestis evolution are largely unexplored. Here, we describe a set of ancient plague genomes up to 5,000 y old from across Eurasia. Our data demonstrate that two genetically distinct forms of Y. pestis evolved in parallel and were both distributed across vast geographic distances, potentially occupying different ecological niches. Interpreted within the archeological context, our results suggest that the spread of plague during this period was linked to increased human mobility and intensification of animal husbandry.

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2116722119

Reference100 articles.

1. Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago

2. Emergence and Spread of Basal Lineages of Yersinia pestis during the Neolithic Decline

3. The Stone Age Plague and Its Persistence in Eurasia

4. A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis

5. Plague dynamics are driven by climate variation

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