The synthetic artificial stem cell (SASC): Shifting the paradigm of cell therapy in regenerative engineering

Author:

Shah Shiv123ORCID,Esdaille Caldon Jayson12ORCID,Bhattacharjee Maumita12,Kan Ho-Man12,Laurencin Cato T.12345ORCID

Affiliation:

1. Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030;

2. Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT 06030;

3. Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269;

4. Department of Orthopedic Surgery, University of Connecticut Health, Farmington, CT 06030;

5. Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269;

Abstract

Significance This paper presents the synthetic artificial stem cell (SASC) system: a versatile therapy which provides the ability to tailor paracrine responses of different cells and provide a more potent regenerative effect for targeted tissues. Upon challenging the SASC system against an osteoarthritis model, we demonstrate that the factors combined tailored for chondrogenesis have a potent antiinflammatory and chondroprotective effect. This paper also demonstrates the in vivo capacity of SASC to attenuate proteoglycan depletion in the cartilage extracellular matrix while also improving biomechanical properties of the resulting cartilage. We report the first of many applications of the SASC system, which provides a promising step toward clinical translation of a minimally immunogenic stem cell with many commercial advantages over its biological counterpart.

Funder

HHS | National Institutes of Health

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

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