Affiliation:
1. B CUBE Center for Molecular Bioengineering, Technische Universität Dresden, 01307 Dresden, Germany
Abstract
Significance
Lipids, which are essential for life and one of the most ancient biomolecules, can spontaneously self-assemble to form membranous bilayers, theoretically providing a surface that can serve to concentrate, protect, and regulate RNAs. Here, we show that direct RNA–lipid interactions can modulate ribozyme activity in a lipid-dependent manner. We further demonstrate that RNA–lipid binding is influenced by nucleotide content and base pairing of RNAs. This yields an essential framework for engineering RNA–lipid systems that can be regulated based on sequence specificity and introduces a mechanism for riboregulation in cellular, synthetic, and prebiotic systems.
Funder
Bundesministerium für Bildung und Forschung
Volkswagen Foundation
Publisher
Proceedings of the National Academy of Sciences
Cited by
22 articles.
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