Correlation between structure and function in phosphatidylinositol lipid–dependent Kir2.2 gating-Reference-Cited by-同舟云学术

Correlation between structure and function in phosphatidylinositol lipid–dependent Kir2.2 gating

Published:2022-03-14 Issue:12 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Zhang Yuxi¹^ORCID,Tao Xiao¹,MacKinnon Roderick¹

Affiliation:

1. Laboratory of Molecular Neurobiology and Biophysics, HHMI, The Rockefeller University, New York, NY ,10065

Abstract

Significance Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2 ) levels regulate cell membrane voltage by gluing two halves of a K + channel together and opening the pore. PI(4)P competes with this process. Because both of these lipids are relatively abundant in the plasma membrane and are directly interconvertible through the action of specific enzymes, they may function together to regulate channel activity.

Funder

HHS | NIH | National Institute of General Medical Sciences

Howard Hughes Medical Institute

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2114046119

Reference37 articles.

1. Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish.

2. The anomalous rectification and cation selectivity of the membrane of a starfish egg cell

3. B. Hille , Ion Channels of Excitable Membranes (Sinauer Associates, Sunderland, MA, 2001).

4. Ionic currents underlying activity in the giant axon of the squid;Hodgkin A. L.;Arch. Sci. Physiol. (Paris),1949

5. The influence of potassium and chloride ions on the membrane potential of single muscle fibres

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