Darwinian genomics and diversity in the tree of life

Author:

Stephan Taylorlyn1ORCID,Burgess Shawn M.1ORCID,Cheng Hans2,Danko Charles G.3ORCID,Gill Clare A.4,Jarvis Erich D.56,Koepfli Klaus-Peter78,Koltes James E.9ORCID,Lyons Eric10ORCID,Ronald Pamela11121314ORCID,Ryder Oliver A.1516ORCID,Schriml Lynn M.17,Soltis Pamela18ORCID,VandeWoude Sue19ORCID,Zhou Huaijun20,Ostrander Elaine A.1ORCID,Karlsson Elinor K.212223

Affiliation:

1. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20817

2. Avian Disease and Oncology Laboratory, Agricultural Research Service, US Department of Agriculture, East Lansing, MI 48823

3. Department of Biomedical Sciences, Baker Institute for Animal Health, Cornell University, Ithaca, NY 14850

4. Department of Animal Science, Texas A&M University, College Station, TX 77843

5. Laboratory of Neurogenetics of Language, The Rockefeller University, New York, NY 10065

6. HHMI, Chevy Chase, MD 20815

7. Smithsonian-Mason School of Conservation, George Mason University, Front Royal, VA 22630

8. Smithsonian Conservation Biology Institute, National Zoological Park, Washington, DC 20008

9. Department of Animal Science, Iowa State University, Ames, IA 50011

10. School of Plant Sciences, BIO5 Institute, University of Arizona, Tucson, AZ 85721

11. Department of Plant Pathology, University of California, Davis, CA 95616

12. The Genome Center, University of California, Davis, CA 95616

13. The Innovative Genomics Institute, University of California, Berkeley, CA 94720

14. Grass Genetics, Joint Bioenergy Institute, Emeryville, CA 94608

15. San Diego Zoo Wildlife Alliance, Escondido, CA 92027

16. Department of Evolution, Behavior, and Ecology, University of California San Diego, La Jolla, CA 92093

17. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201

18. Florida Museum of Natural History, University of Florida, Gainesville, FL 32611

19. Department of Micro-, Immuno-, and Pathology, Colorado State University, Fort Collins, CO 80532

20. Department of Animal Science, University of California, Davis, CA 95616

21. Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01655

22. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655

23. Broad Institute of MIT and Harvard, Cambridge, MA 02142

Abstract

Genomics encompasses the entire tree of life, both extinct and extant, and the evolutionary processes that shape this diversity. To date, genomic research has focused on humans, a small number of agricultural species, and established laboratory models. Fewer than 18,000 of ∼2,000,000 eukaryotic species (<1%) have a representative genome sequence in GenBank, and only a fraction of these have ancillary information on genome structure, genetic variation, gene expression, epigenetic modifications, and population diversity. This imbalance reflects a perception that human studies are paramount in disease research. Yet understanding how genomes work, and how genetic variation shapes phenotypes, requires a broad view that embraces the vast diversity of life. We have the technology to collect massive and exquisitely detailed datasets about the world, but expertise is siloed into distinct fields. A new approach, integrating comparative genomics with cell and evolutionary biology, ecology, archaeology, anthropology, and conservation biology, is essential for understanding and protecting ourselves and our world. Here, we describe potential for scientific discovery when comparative genomics works in close collaboration with a broad range of fields as well as the technical, scientific, and social constraints that must be addressed.

Funder

NSF | BIO | Division of Integrative Organismal Systems

USDA | National Institute of Food and Agriculture

HHS | NIH | National Institute of General Medical Sciences

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3