Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion-Reference-Cited by-同舟云学术

Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion

Published:2022-04-08 Issue:15 Volume:119 Page:
ISSN:0027-8424
Container-title:Proceedings of the National Academy of Sciences
language:en
Short-container-title:Proc. Natl. Acad. Sci. U.S.A.

Author:

Xie Lili¹²^ORCID,Cen Ling-Ping¹²³^ORCID,Li Yiqing¹²⁴^ORCID,Gilbert Hui-Ya¹²^ORCID,Strelko Oleksandr¹²^ORCID,Berlinicke Cynthia⁵⁶⁷⁸,Stavarache Mihaela A.⁹^ORCID,Ma Madeline¹²,Wang Yongting¹⁰^ORCID,Cui Qi¹²³,Kaplitt Michael G.⁹^ORCID,Zack Donald J.⁵⁶⁷⁸^ORCID,Benowitz Larry I.¹²¹¹¹²^ORCID,Yin Yuqin¹²^ORCID

Affiliation:

1. Department of Neurosurgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115

2. F. M. Kirby Neurobiology Center, Boston Children’s Hospital, Boston, MA 02115

3. Joint Shantou International Eye Center, Shantou University and The Chinese University of Hong Kong, Shantou 515000, China

4. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510085, China

5. Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287

6. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287

7. Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287

8. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287

9. Laboratory of Molecular Neurosurgery, Department of Neurological Surgery, Weill Cornell Medical College, New York, NY 10065

10. School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

11. Department of Ophthalmology, Harvard Medical School, Boston, MA 02115

12. Program in Neuroscience, Harvard Medical School, Boston, MA 02115

Abstract

Significance The optic nerve conveys information from retinal ganglion cells (RGCs) to visual processing areas of the brain. Although this pathway normally cannot regenerate when injured nor in degenerative diseases such as glaucoma, this failure can be partially reversed by eliciting a controlled immune reaction in the eye. We show here that the chemokine SDF1 (stromal cell–derived factor 1) is an important contributor to this phenomenon. SDF1 is produced by infiltrative monocytes and acts through its cognate receptor to enhance RGC survival, promote optic nerve regeneration, and sensitize subtypes of RGCs that normally fail to respond to a complementary treatment to exhibit robust, long-distance regeneration. These findings establish SDF1 as an important therapeutic candidate for repairing the injured optic nerve.

Funder

HHS | NIH | National Eye Institute

Publisher

Proceedings of the National Academy of Sciences

Subject

Multidisciplinary

Link

https://pnas.org/doi/pdf/10.1073/pnas.2113751119

Reference90 articles.

1. Requirement of Myeloid Cells for Axon Regeneration

2. Inflammation and axonal regeneration

3. Contribution of Macrophages to Enhanced Regenerative Capacity of Dorsal Root Ganglia Sensory Neurons by Conditioning Injury