Sharp, localized phase transitions in single neuronal cells

Abstract

Significance Phase transitions in materials are accompanied by drastic changes in their properties. Systems abruptly become softer, more conductive, have better heat storage, or support chemical reactions more efficiently. Since changes take place over small variations in external conditions (tension, temperature, pH, calcium), they appear like an on/off switch. Here, we provide experimental evidence that membrane patches of single living cells can go through a reversible phase transition. It is extremely “sharp” (highly nonlinear), and from a thermodynamic point of view we conclude it cannot only be triggered by temperature but also by pH changes (as produced by enzymes). The results strongly support the idea that phase transitions may be a tool for living systems to control their functions even specifically.